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The abnormalities included the presence of an abnormally high number of both beta cells and alpha cells--more than three times greater than normal and the fact that these cells were arranged in "eccentric" islets that were proliferating into the pancreatic ducts in an unusual way.

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Low blood sugar (hypoglycemia) and weight gain are the main side effects of insulin therapy.

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Talked with my doctor and ask him to put me on this, he was reluctent, i am a 48 yr old female, and have had type II diabetes since i was 24.

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Effects of the triple reuptake inhibitor amitifadine on extracellular levels of monoamines in rat brain regions and on locomotor activity".

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Magnesium does seem to bind oxalate, but there is more known about calcium.

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It can be used alone or in combination with metformin or a thiazolidinedione drug.

My doctor has wanted me to start Insulin injections, which is a very scary thought because I simply hate needles of any kind.

Sulfonylureas are oral drugs that stimulate the pancreas to release insulin.

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Benfotiamine can simultaneously block three of the major biochemical pathways responsible for the blood-vessel damage that causes serious diabetic complications.

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Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); fever, chills, or persistent sore throat; red, blistered, swollen, or peeling skin; symptoms of pancreas inflammation (eg, severe stomach or back pain with nausea or vomiting, stomach tenderness or swelling, fast heartbeat, dizziness).

But the thing that doctors don't seem to understand is that the people it works well for are those people who, like me, though diagnosed as "insulin resistant type 2s" are, as I am, insulin sensitive people whose beta cells due to some flaw have stopped secreting insulin in response to rising blood sugar.

WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider.

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This is my first weekend on Byetta and I'm relieved.

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It means if you are taking these drugs and you develop pancreatic cancer, it is more likely than not you got it as the result of using these diabetes drugs.

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Thiazolidinediones available as 2-in-1 pills include rosiglitazone and metformin (Avandamet), rosiglitazone and glimepiride (Avandaryl), and pioglitazone and glimepiride (Duetact).

I've been on Januvia for a little over three months and have lost over 15 pounds which I had put on with Actos.

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The fact that it does help control my blood sugar is a big positive; however, it has increased my appetite two fold.

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The main issue is that either of them should be used with meals so the binding process takes place in the gut and prevents the absorption of oxalate.

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Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training.

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Co-administration of a single 100-mg oral dose of sitagliptin and a single 600-mg oral dose of cyclosporine increased the AUC and C max of sitagliptin by approximately 29% and 68%, respectively.

When pramlintide is initiated, the insulin dosage should be reduced by 50 percent to avoid potentially severe hypoglycemia.

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Several research studies have concluded that these drugs may increase the risk of pancreatitis and pancreatic cancer.

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When I read the insert to the Janumet Medicine, it indicated that a symptom of Lactic Acidosis would be (unfamiliar) muscle pain.

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In controlled clinical studies as both monotherapy and combination therapy with metformin or pioglitazone, the overall incidence of adverse reactions, hypoglycemia, and discontinuation of therapy due to clinical adverse reactions with JANUVIA were similar to placebo.

You should also inform your doctor about all your medical conditions including a history of inflammation of the pancreas (pancreatitis), allergies, kidney problems or breast feeding.

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If you did not have a dramatically intense hypo reaction to glipizide the most common forms of MODY are less likely.

In my experience Novolog or Apidra work much faster than Humalog (or R) and are often a much better choice for controlling meals than what he suggests.

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Made by Boehringer Ingelheim and Eli Lilly and Company, it was the first DPP-4 to be approved in one standard dose of 5 mg, regardless of kidney or liver impairment, age, or weight.

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SITAGLIPTIN (sit a GLIP tin) helps to treat type 2 diabetes.

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Also, a higher HbA1c goal may be appropriate for certain patients, including those with a history of repeated episodes of low blood sugar, coronary heart disease, stroke or limited life expectancies.

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Glipizide was making me sick, so new Dr started me on Januvia.

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However, inhibition of DPP-4 also causes levels of GLP-2, GIP, and other gut peptides to rise.

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However DPP-4 is used by the immune system for other functions most doctors know nothing about.

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